Hypothermia Clinical Trial
Animal
Delay in cooling negates the beneficial effect of mild resuscitative cerebral hypothermia after cardiac arrest in dogs: A prospective, randomized study: Kazutoshi, Safar, Radovsky, et al. – Critical Care Medicine, September 1993.
Human
Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest (PDF) The Hypothermia after Cardiac Arrest Study Group – The New England Journal of Medicine, February 21, 2002.
Treatment of Comatose Survivors of Out-of-Hospital Cardiac Arrest with Induced Hypothermia: (PDF) Bernard, Gray, Buist, et al – The New England Journal of Medicine, February 21, 2002.
Induced Hypothermia using large volume, ice-cold intravenous fluid in comatose survivors of out-of-hospital cardiac arrest: a preliminary report (PDF) Bernard, Montiero, Smith, et al – Resuscitation, September, 2003.
Pilot Study of Rapid Infusion of 2 Liters of 4° Centigrade Normal Saline for Induction of Mild Hypothermia in Hospitalized Survivors of Cardiac Arrest, Kim, et al. Circulation 2005.